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KMID : 0369819970270020119
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 2 p.119 ~ p.123
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Structural and Physicochemical Studies on DA - 5018 , a New Capsaicin Derivative
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김흥재/Kim HJ
이종진/이응두/심현주/이상득/옥광대/김원배/Lee JJ/Lee ED/Shim HJ/Lee SD/Ok KD/Kim WB
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Abstract
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The physicochemical and structural properties of new capsaicin derivative, DA-5018, were examined. The reference standard of this compound was obtained by the recrystallization. A method for the determination of the dissociation constant of the compound is described. pH-solubility and distribution coefficient were determined by chromatographic method. Fundamental properties on thermal behaviors were investigated by TG, DTA and DSC. Structural analysis based on spectroscopic method coincided with the chemical structure of DA-5018. Approximate dissociation constant of the compound determined by UV spectral method was 9.35. Solubilities and partition coefficients in various pH buffer solution appeared pH-dependency. No crystal transition or further transition was found in the thermal analysis. This compound showed good stability, but pH 13 buffer and acetone made some degradative products.
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KEYWORD
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DA-5018, Solubility, Dissociation constant, Partition coefficient, Thermal analysis, Capsaicinoid
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